Anti-cardiolipin (aCL) autoimmune antibodies are a subset of antibodies which react with negatively charged phospholipids. Anti-cardiolipin antibodies are frequently observed in patients with SLE. One autoantibody, LA, is measured with a bioassay and the other autoantibody, aCL, is measured based on affinity for cardiolipin. In many cases both autoantibodies are present in a single patient and may be the same antibody in some cases.
During the 1990\’s the complex interaction of a common serum protein, beta-2 glycoprotein, and a fatty acid, phosphotydl serine, was defined and shown to be a specific and diagnostic antibody response. Kits designed before the 1990\’s did not reliably detect anti-beta-2 glycoprotein, the most significant disease specific component. GenBio\’s kits not only detects this important beta-2 glycoprotein reaction, but assures its reproducible and sensitive measurement by standardizing the phosphotydl serine concentration. This means the ImmunoWELL Caridiolipin kit reproducibly and simultaneously measures total cardiolipin and the more significant clinical marker, anti-beta-2 glycoprotein.